SPATA 2 promotes CYLD activity and regulates TNF ‐induced NF ‐κB signaling and cell death
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منابع مشابه
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
K63- and Met1-linked ubiquitylation are crucial posttranslational modifications for TNF receptor signaling. These non-degradative ubiquitylations are counteracted by deubiquitinases (DUBs), such as the enzyme CYLD, resulting in an appropriate signal strength, but the regulation of this process remains incompletely understood. Here, we describe an interaction partner of CYLD, SPATA2, which we id...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2016
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201642592